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Phentermine is absorbed through the gastrointestinal tract and reaches peak concentrations in the blood in three to 4.4 hours, by which time you should start feeling the effects, alerting you that the drug is working.

Before you take Duromine

When you must not take it

Do not take Duromine if you have an allergy to:

• any medicine containing phentermine
• any of the ingredients listed at the end of this leaflet
• any other similar medicines used to reduce weight

Some of the symptoms of an allergic reaction may include:

• shortness of breath
• wheezing or difficulty breathing
• swelling of the face, lips, tongue, or other parts of the body
• rash, itching or hives on the skin

Do not give this medicine to a child under the age of 12 years.

Safety and effectiveness in children younger than 12 years have not been established.

Do not take this medicine if you have any of the following medical conditions:

• very high blood pressure
• high blood pressure in the lung
• problems with the valves in your heart
• disease-related to blood vessels in the brain
• severe heart disease including changes in the rhythm or rate of the heart beat
• narrowing of the blood vessels due to thickening or hardening of the blood vessel wall
• overactive thyroid gland
• psychiatric illness including anorexia nervosa (loss of appetite) and depression
• glaucoma (high pressure in the eye)

Do not use this medicine:

• if you are currently taking, or have taken within the last 14 days, antidepressant medicines from the monoamine oxidase inhibitors (MAOI) class such as phenelzine (eg Nardil) or tranylcypromine (eg Parnate).
• if you have previously misused drugs or alcohol